Professor Tom Monie

Institute of Continuing Education (ICE)

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Biography

Professor Tom Monie is the Senior Tutor at Christ’s College, University of Cambridge. He is responsible for the education and wellbeing of over 400 undergraduate and around 300 postgraduate students.

He is a Professor of Pure and Applied Biomedical Sciences and a protein biochemist by training with a long-standing interest in infection, immunity and genetics. Previously he has run a research group investigating the shapes and structures of molecules involved in recognising bacterial infection and has overseen and taught on a wide range of undergraduate and postgraduate courses in the biological and medical sciences. These include courses in Genetics, Evolutionary Biology, Infection and Immunity, Medical Education, Genomic Medicine and Healthcare Data amongst others. Tom's extensive experience in teaching within the University includes undergraduate supervisions, practical classes and lectures along with a wide-range of postgraduate teaching and the education of adult and professional learners. His research publication topics have included topics such as cat allergy- which was a global media story- Crohn's Disease, inherited auto-inflammatory genetic diseases, species variation in immunity and inflammation, and protein function in the immune system.

Many students have benefitted from his involvement in a wide range of teaching activities targeted at the provisions of subject-specific and transferable skills for graduate students. Tom is a firm believer that learning should be fun, that student participation is central to this process, and that successful teaching requires responsiveness to the needs of the students. He aims to instil these elements into his teaching and engagement activities.

Qualifications:

MA Natural Sciences, University of Cambridge

PhD Molecular Virology, University of Cambridge

BA Natural Sciences, University of Cambridge

Research

Tom’s long standing interests in the biology of diseases and protein biochemistry are successfully combined through his research investigating how the innate immune system detects and responds to danger. He held a prestigious Wellcome Trust Fellowship from 2008 to 2014 to study two members, NOD1 and NOD2, of the NLR family of cytoplasmic immune receptors.

Tom’s current research focuses on studying protein:protein interactions to work out how innate immune signalling pathways function. This includes continuing to work out the mechanism by which NOD1 and NOD2 detect and respond to danger, and how mutations in the NOD2 protein lead to the development of autoinflammatory conditions such as Crohn’s Disease and Blau Syndrome.

Tom uses a range of experimental approaches in his research including computational modelling of protein structure to work out the impact of mutations on their structure and function.

Selected Publications

JOURNAL ARTICLES

Pereira M, Tourlomousis P, Wright J, Monie TP & Bryant CE. CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. Nature Communications. 7, 12874 doi:10.1038/ncomms12874 , 2016
Lanucara F, Lam C, Mann J, Monie TP, Colombo SA, Holman SW, Boyd J, Dange MC, Mann DA, White MR, Eyers CE. Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription. Open Biol. Jul;6(7). pii: 160055. doi:10.1098/rsob.160055 , 2016
Jain L, Gupta N, Reddy MM, Mittal R, Barik MR, Panigrahi B, Monie T, Basu S. A Novel Mutation in Helical Domain 2 of NOD2 in Sporadic Blau Syndrome. Ocul Immunol Inflamm. Sep 13:1-3. doi: 10.1080/09273948.2016.1207789 , 2016
Robertson J, Haas CT, Pele LC, Monie TP, Charalambos C, Parkes M, Hewitt RE, Powell JJ. Intestinal APCs of the endogenous nanomineral pathway fail to express PD-L1 in Crohn's disease. Sci Rep. May 26;6:26747. doi: 10.1038/srep26747 , 2016
Monie TP, Bryant CE. Allergens and Activation of the Toll-Like Receptor Response. Methods Mol Biol. 1390:341-50. doi: 10.1007/978-1-4939-3335-8_21 , 2016
Monie TP, Gay NJ, Gangloff M. Bioinformatic Analysis of Toll-Like Receptor Sequences and Structures. Methods Mol Biol.1390:29-39. doi: 10.1007/978-1-4939-3335-8_2 , 2016
Parkhouse R, Monie TP. Dysfunctional Crohn's Disease-Associated NOD2 Polymorphisms Cannot be Reliably Predicted on the Basis of RIPK2 Binding or Membrane Association. Front Immunol. Oct 8;6:521. doi: 10.3389/fimmu.2015.00521 , 2015
Monie TP, Bryant CE. Caspase-8 functions as a key mediator of inflammation and pro-IL-1β processing via both canonical and non-canonical pathways. Immunol Rev. May;265(1):181-93. doi: 10.1111/imr.12284 , 2015
Bryant CE, Orr S, Ferguson B, Symmons MF, Boyle JP, Monie TP. International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol Rev. 67(2):462-504. doi: 10.1124/pr.114.009928 , 2015
Boyle JP, Parkhouse R, Monie TP. Insights into the molecular basis of the NOD2 signalling pathway. Open Biol. Dec;4(12). pii: 140178. doi: 10.1098/rsob.140178 , 2014
Parkhouse R, Boyle JP, Monie TP. Blau syndrome polymorphisms in NOD2 identify nucleotide hydrolysis and helical domain 1 as signalling regulators. FEBS Lett. Sep 17;588(18):3382-9. doi: 10.1016/j.febslet.2014.07.029 , 2014
Parkhouse R, Boyle JP, Mayle S, Sawmynaden K, Rittinger K, Monie TP. Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain. FEBS Lett. Aug 25;588(17):2830-6. doi: 10.1016/j.febslet.2014.06.035 , 2014
Mayle S, Boyle JP, Sekine E, Zurek B, Kufer TA, Monie TP. Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction. J Biol Chem. Aug 15;289(33):22900-14. doi: 10.1074/jbc.M114.557900 , 2014
Man SM, Hopkins LJ, Nugent E, Cox S, Glück IM, Tourlomousis P, Wright JA, Cicuta P, Monie TP, Bryant CE. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc Natl Acad Sci U S A. May 20;111(20):7403-8. doi: 10.1073/pnas.1402911111 , 2014
Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J Immunol. Nov 15;191(10):5239-46. doi: 10.4049/jimmunol.1301581 , 2013

Memberships

Member of the Biochemical Society

Member of the American Society for Biochemistry and Molecular Biology

Editorial Board Member of the Journal of Biological Chemistry

Editorial Board Member of Molecular Innate Immunity, Frontiers in Immunology

Editorial Board Member of Inflammation, Frontiers in Immunology

Courses taught

Postgraduate Certificate in Clinical Research, Education and Leadership | Postgraduate courses

MSt in Clinical Medicine | Master's degrees

Past courses taught

Immunology and infection: a beginner's guide | Summer Programme course

Clinical Research | Postgraduate Modules

Immunology and infection: a beginner’s guide | Summer Programme course

Clinical Research | Postgraduate Modules

Postgraduate Certificate in Clinical Research, Education and Leadership | Postgraduate Certificate/Diploma awards

MSt in Clinical Medicine | Part-time Master's Degree

Postgraduate Certificate in Healthcare Data and Informatics | Postgraduate Certificate/Diploma awards

Postgraduate Certificate in Advanced Clinical Practice (PHEM) | Postgraduate Certificate/Diploma awards

MSt in Clinical Medicine | Part-time Master's Degree

Immunology and infection: a beginner’s guide | Summer Programme course

Undergraduate Diploma in Genetics | Undergraduate Certificate/Diploma

Undergraduate Certificate in Evolutionary Biology | Undergraduate Certificate/Diploma

Undergraduate Certificate in Entrepreneurship: Venture Creation | Undergraduate Certificate/Diploma

Postgraduate Diploma in Clinical Medicine | Postgraduate Certificate/Diploma awards

Postgraduate Certificate in Clinical Research, Education and Leadership | Postgraduate Certificate/Diploma awards

Postgraduate Certificate in Healthcare Data and Informatics | Postgraduate Certificate/Diploma awards

Postgraduate Diploma in Healthcare Data: Informatics, Innovation and Commercialization | Postgraduate Certificate/Diploma awards

MSt in Healthcare Data: Informatics, Innovation and Commercialization | Part-time Master's Degree

MSt (flexible) in Healthcare Data: Informatics, Innovation and Commercialization | Part-time Master's Degree

Postgraduate Diploma (Flexible) in Healthcare Data: Informatics, Innovation and Commercialization | Postgraduate Certificate/Diploma awards

Postgraduate Certificate in Research and Innovation Leadership (Apprenticeship) | Apprenticeship awards

Postgraduate Certificate in Advanced Clinical Practice (PHEM) | Postgraduate Certificate/Diploma awards

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